08.30-10.00 Session 10 (Branding)
NVE teaching session From bench to bedside: molecular biology and clinical aspects of the pituitary adrenal ensemble
Chairperson: Hans Romijn (Leiden)
Ron de Kloet (Leiden): Fundamental aspects of hypothalamic-pituitary-adrenal regulation (30) (pdf)
Sonia Lupien (Lasalle, Canada): The effects of glucocorticoids on cognition function in human (30) (pdf)
Ad Hermus (Nijmegen): Disorders of the pituitary-adrenal axis (30)

10.00-10.30 Break

10.30-12.00 Parallel sessions

Session 11 (Doorwerth)
The autonomic nervous system links the symptoms of the metabolic syndrome
Chairpersons: Felix Kreier and Ruud Buijs (Amsterdam)
Anthony Cincotta (Tiverton, MA, USA): Monoaminergic circuits in the control of fuel metabolism (30)
Marco van den Top (Coventry, UK): Orexigen-sensitive pacemaker neurons in the hypothalamic arcuate nucleus (15) (pdf)
Lucien Harthoorn (Amsterdam): Multi-transcriptional profiling of hypothalamic neurons: different functionalities in the control of energy homeostasis (15) (pdf)
Anita van den Hoek (Leiden): Central effects on glucose metabolism (15) (pdf)
Ajda Yilmaz (Amsterdam): The clock is ticking on the vessel wall: parasympathetically mediated vasodilation in skeletal muscle (15) (pdf)

Session 12 (Gelderland)
Thyroid hormone and brain development
Chairperson: Theo Visser (Rotterdam)
Douglas Forrest (New York, NY, USA):Role of thyroid hormone receptors in brain development (30) (pdf)
Edith Friesema (Rotterdam): Role of transporters in thyroid hormone trafficking in the developing brain (15) (pdf)
Monique Kester (Rotterdam): Regulation of local thyroid bioactivity in the developing brain by deiodinases (15) (pdf)
Anneke Alkemade (Amsterdam): Hypothalamic regulation of the human pituitary-thyroid axis (15) (pdf)
Aleid van Wassenaer (Amsterdam): Importance of thyroid hormone for human brain development (15) (pdf)

Session 13 (Patio)
Kinases and phosphatases
Moderator: (Eddy van der Zee, Groningen)
Eric Klann (Houston, Texas, USA): Protein kinase and phosphatase cascades and synaptic plasticity (45) (pdf)
Marloes Kolkman (Nijmegen): The influence of protein tyrosine phosphatases on mouse behaviour (15) (pdf)
Pim French (Rotterdam): LTP- and behavioral-associated expression of Pde10A phosphodiesterase splice variants (15) (pdf)
Robbert Havekes (Groningen): Protein phosphatases and remodeling of existing hippocampal dependent memory (15) (pdf)

Session 14 (Branding)
Stress and psychopathology
Chairperson: Liselotte van der Kam (Nijmegen)
Nick Goeders (Shreveport, LA, USA): Impact of stress on addictive behavior (30) (pdf)
Liselotte van der Kam (Nijmegen): The influence of environmental conditions on cocaine self- administration (15) (pdf)
Melly Oitzl (Leiden): Stress and glucocorticoids: companions in health and disease (30) (pdf)
Jaap Koolhaas (Groningen): Individuals, stress and reactivity: causes and consequences (15)

12.00-13.30 Lunch (Paviljon)

13.30-15.00 Parallel sessions

Session 15 (Doorwerth)
Pathological protein aggregation during aging
Chairpersons: Jo Höppener (Utrecht) and Fred van Leeuwen (Amsterdam)
Ron Kopito (Stanford, USA): Impairment of the ubiquitin-proteasome system by protein aggregation (30) (pdf)
Remko de Pril (Amsterdam): Aggregate formation and cell death in polyglutamine diseases (15) (pdf)
Maarten Engel (Utrecht): Islet amyloidosis and type 2 diabetes mellitus (15) (pdf)
David Fischer (Amsterdam): Molecular misreading and Alzheimer's disease (15) (pdf)
Barend Bouma (Utrecht): Activation of tissue-type plasminogen activator by amyloid cross-ß structure (15) (pdf)

Session 16 (Patio)
Intracellular signal transduction in neuroendocrine systems
Chairpersons: Wim Scheenen and Bruce Jenks (Nijmegen)
Martin Muschol (Pennsylvania, USA): A tale of two hormones: stimulus-secretion coupling in magnocellular hypothamalic neurons (30) (pdf)
Jur Koksma (Amsterdam): GABA synaps plasticity in oxytocin neurons (15) (pdf)
Hongyan Zhang (Nijmegen): Regulation of VOCC by GiPCR: D2-receptor is twice as strong as the GABAb-receptor (15) (pdf)
Maarten van der Hurk (Nijmegen): Signal transduction of the Ca-sensing receptor in Xenopus melanotropes (15) (pdf)
Jan Bogerd (Utrecht): How to make an FSH receptor into an LHR? ('Just blink twice') (15) (pdf)

Session 17 (Branding)
Laser microdissection and expression analysis
Moderators Elly Hol (Amsterdam) and Eric Boddeke (Groningen)
(sponsored by P.A.L.M. Microlaser Technologies, Bernried, Germany)
Stephen Ginsberg (New York, NY, USA): Single cell analysis in neurodegenerative diseases, RNA amplification (30) (pdf)
Dimitra Kontostavlaki (Amsterdam): Catecholamine-synthethizing enzymes in human hypothalamic neurons (15) (pdf)
Freddy de Bree (Amsterdam): LDM and microarray analysis on rat olfactory system (15) (pdf)
Karin Schütze (Bernried, Germany): Laser microdissection and catapulting technology (30) (pdf)

Session 18 (Gelderland)
Protein synthesis in the neurite
Chairperson: Jan van Minnen (Amsterdam)
Jeffery Twiss (Wilmington, DE, USA): Regulation of local protein synthesis in regenerating axons (45) (pdf)
Carolina Jost (Leiden): Towards the visualization of mRNA transport to the synaps (15) (pdf)
Ronald van Kesteren (Amsterdam): Regulation of actin dynamics by local protein synthesis in neuronal growth cones (15) (pdf)
Jan van Minnen (Amsterdam): Transcellular transport of ribosomes from Schwann cells to axons (15) (pdf)

15.00-17.00 Poster session Neuroscience 1 (Branding)

17.00-18.30 Parallel sessions

Session 19 (Patio)
New avenues for peripheral nerve repair
Moderator: Gerard Boer (Amsterdam)
Martijn Malessy (Leiden): Current clinical problems in peripheral nerve and spinal root repair (30) (pdf)
Marcel Meek (Groningen): Biodegradable nerve conduits for peripheral nerve repair; should or shouldn't we use them?(15) (pdf)
Carmen Vleggeert-Lankamp (Leiden): Tissue engineering for peripheral nerve repair (15) (pdf)
William Hendriks (Amsterdam): Application of viral vector-mediated gene therapy to promote peripheral nerve regeneration (15) (pdf)
Remy Wiertz (Enschede): Neurochips, a device for in vivo repair of complex peripheral neuronal circuits? (15) (pdf)

Session 20 (Gelderland)
Parkinson's disease: not by dopamine alone
Chairpersons: Henk Berendse and Benjamin Drukarch (Amsterdam)
Thomas Hummel (Dresden, Germany): What comes first in Parkinson's disease symptomatology? Olfactory dysfunction as an early clinical sign (30) (pdf)
Bart Scholtissen (Maastricht): Depression as an early sign of Parkinson's disease: involvement of serotonergic mechanisms (15) (pdf)
Kelly Del Tredici (Frankfurt am Main, Germany): Where does Parkinson's disease pathology begin in the brain? (15) (pdf)
Piet Hoogland (Amsterdam): Hyposmia and the paradox of dopamine in Parkinson's disease (15) (pdf)
Gerda Andringa (Amsterdam): An unifying mechanism underlying dopaminergic and non-dopaminergic degeneration in Parkinson's disease? (15) (pdf)

Session 21 (Doorwerth)
Cytoskeletal rearrangements underlying changes in synaptic efficacy
Chairpersons: Pim French (Rotterdam)
Andrew Matus (Basel, Switzerland): Regulation of synaptic plasticity by the actin cytoskeleton (45) (pdf)
Marja Miedema (Rotterdam): The differentiation of axons and dendrites is accompanied by changes in microtubule polarity: visualization of dynamic growth in cultured Purkinje neurons (15) (pdf)
Ger Ramakers (Amsterdam): Of mice and men: linking cytoskeletal dynamics and spines to cognition (15) (pdf)
Simone Houtman (Rotterdam): Neuronal plasticity regulated by the cytoskeletal associated proteins Eml1, Eml4 and synaptopodin (15) (pdf)

Session 22 (Branding)
The genetic dissection of complex behavioral traits
Moderator: Martien Kas (Utrecht)
Lindsay Burrage (Cleveland, USA): Genetic dissection of complex traits in the mouse (45) (pdf)
Leonie de Visser (Utrecht): Behavioral phenotyping in the mouse (15) (pdf)
Femke Streijger (Nijmegen): Double mutant analysis in the mouse (15) (pdf)
Mariska van der Plas (Leiden): Genetic strategies in the neurobiology of the fruitfly (15) (pdf)

19.00 Dinner
Poster Award Ceremony Neuroscience 1

21.00-21.45 Session 23 (Branding)
Hersenstichting Lecture
Chairperson: Ineke van der Zee (Nijmegen)
Dick Swaab (Amsterdam): Sexual differentiation of the human brain (pdf)