PROGRAM Tuesday, June 5

'Marius Tausk' lecture 
(chair: Ron de Kloet, Leiden)
Aaron Hsueh (Stanford, USA)
Hormone research in the postgenomic era 
  

Parallel sessions

Session 1
OVARIES AND GENOMICS
(chair: Katja Teerds, Utrecht)
Steve Franks (London, UK)
Aetiology of polycystic ovarary syndrome: insights from molecular, cellular and physiological studies (30)
Jenny Visser (Rotterdam)
Identification of the anti-Müllerian hormone signal transduction pathway and its implications for female aging (30)
Rubin Hundscheid (Nijmegen)
FSH in female members of fragile-X families (15)
John Martens (San Francisco, CA, USA)
Transcriptional regulation of the human gene for p450c17 (steroid 17a-hydroxylase/17,20 lyase) (15)

Session 2
Thyroid and heart
(chair: Marjanne Everts, Utrecht and Warner Simonides, Amsterdam) 
Warner Simonides (Amsterdam)
Role of thyroid hormone in heart failure (30)
Arie Berghout (Rotterdam)
Thyroid heart disease: questions of a clinician to basic research (15)
Haidy van der Putten (Utrecht)
Transport of thyroid hormone in cultured heart cells (15)
Frank Wassen (Rotterdam)
Regulation of hyroid hormone metabolism in heart (15)
Mieke van Beeren (Amsterdam)
Interaction of the new anti-arythmic drug deonedarone with the thyroid hormone receptors a1 and b1 (15)

Session 3
Type 2 diabetes, from population to gene
(chair: Hans Romijn, Leiden)
Tim Frayling (Exeter, UK)  
Variation in the human genome and type 2 diabetes: what have we learnt? (30)
M. Losekoot (Leiden)
Early detection of heriditary subtypes of diabetes mellitus (15)
N. Vaessen (Rotterdam)
Type 2 diabetes and genetic variations in the IGF-1 gene (15)
Leen 't Hart (Leiden)
Association of a variant in the sulphonylurea receptor gene with type 2 diabetes and reduced insulin secretion (15)
Giët Bos (Amsterdam)
Dissection of environmental factors in the pathogenesis of type 2 diabetes (15)
  

Session 5
Novel developments in the genetics of thyroid diseases
(chair: Carrie Ris-Stalpers, Amsterdam)
Jan W.A. Smit (Leiden)
Molecular genetic changes associated with differentiated thyroid cancer (30)
Erwin Pauws (Amsterdam)
The SAGE profile of a differentiated thyroid tumor compared to normal thyroid tissue (15)
Xavier de Deken (Bruxelles, B)
Characterization of two human thyroid proteins from the NADPH oxidase family: components of the H₂O₂ generating system (30)
José Carlos Moreno (Amsterdam)
The role of the thyroid oxidase (ThOx2) in human thyroid pathophysiology (15)

Session 6
THE GENOME IN the germ line
(chair: Willy Baarends and Anton Grootegoed, Rotterdam)
Anton Grootegoed (Rotterdam)
Introduction (30) 
Ans van Pelt (Utrecht)
Establishment of a rat spermatogonial cell line (15)
Cathy Bakker (Rotterdam)
Why is there no extensive CGG repeat growth in the male germ line? (15)
Maureen Eijpe (Wageningen)
Sister chromatid cohesion proteins in mammalian meiosis (15)
Henk Roest (Rotterdam)
Involvement of post-replication repair genes in reproduction (15)

Session 7
Growth hormone secretion disorders  
(chair: Hanno Pijl, Leiden)
Maarten Jansen (Utrecht)
Pit-1 in mice and man (30)
Aart Jan van der Lely (Rotterdam)
GH receptor antagonism in the treatment of acromegaly (30)
Madelon Buijs (Leiden) 
Are obese women GH deficient? (15)
Nienke Biermasz (Leiden) 
GHRH receptor defect: clinical sequelae (15)