PROGRAM Thursday, June 7

Session 22
Genomics AND proteomics in the NEUROSCIENCES (2)
(chair: Jean-Marc Taymans, Guus Smit and Joost Verhaagen, Amsterdam)
Condie Carmack (Palo Alto, USA)
Assessing hybridization specificity in oligonucleotide microarrays (30)
Pascal Bonaventure (La Jolla, USA)  
Gene expression profiling of locus coeruleus suggests that chronic mild stress and antidepressants have a common molecular mechanism (30)
Hadriano Lacerda (Amsterdam)
Identification of target genes related to Alheimer's disease in the postmortem brain using DNA arrays (15)
Connie Jimenez (Amsterdam)
Functional proteomics analysis of lesion-induced changes in the rat sciatic nerve (15)
Floor Stam (Amsterdam)
Gene expression analysis during regeneration of the rat sciatic nerve after lesion (15)
Roos de Jonge (Amsterdam)
Gene expression profiles of the peripheral nervous system (15)

Session 23
SYNAPSE FUNCTION: BIOPHYSICS, BIOCHEMISTRY AND PLASTICITY 
(chair: Arjen Brussaard and Matthijs Verhage, Amsterdam)
Joost Heeroma (Utrecht)
Agrin & acetylcholine dependent receptor clustering (15)
Ron Habets (Amsterdam)
Calcium domains at a calyx-type nerve terminal (15)
Andrei Rozov (Amsterdam)
Postsynaptic mechanisms of short term plasticity at excitatory synapses in the rat neocortex  (15)
Mischa de Rover (Amsterdam)
Cholinergic modulation of GABAergic synaptic transmission in the nucleus accumbens shell (15)
Corette Wierenga (Amsterdam)
Feedforward and feedback inhibition in the hippocampal CA1 area (15)
Andrew Matus (Basel, CH)
Molecular mechanisms of structural plasticity at central synapses (45)

Session 24
Keys, clues and pitfalls in behavioral testing of transgenic AND KNOCKOUT mice
(chair: Ineke van der Zee, Nijmegen and Melly Oitzl, Leiden)
Melly Oitzl (Leiden)
Introduction (15)
Olivier Stiedl (Goettingen, D)
Learning, memory and stress in mice: defensive behavior and heart rate dynamics during fear conditioning (30)
Catharina van der Zee (Nijmegen)
Brain creatine kinase-deficient mice show impaired spatial learning, less habituation and nestbuilding, but increased aggressive behaviour (30)
Arjen Blokland (Maastricht)
Searching the cognitive deficits of knockout and transgenic mice: ruling out alternative explanations (15)
Alexa Veenema (Groningen)
Behavioural and neuroendocrine characteristics of wild house mice genetically selected for high and low aggression: beyond a model for aggression (15)
Saskia Arndt (Köln, D)
The Mutant Mouse Bank (MMB)-network: an instrument for the standardisation of behavioural testing methods? (15)

Session 25
Gender and pathobiology of mood disorders
(chair: Gert ter Horst, Groningen)
Gert ter Horst (Groningen)
Introduction (15)
Andrea Trentani (Groningen)
Chronic mild stress and second messenger cascades in male and female rat forebrain (30)
Yolanda van Beek (Utrecht)
Depression in adolenscence: why more girl? (30)
Mark George (Charleston, USA)
Neuroimaging of gender related brain activity changes in psychiatric disease (45)
 

Session 26
Mental retardation and the neurobiological basis of intelligence
(chair: Hans van Bokhoven, Nijmegen and Ger Ramakers, Amsterdam)
Jamel Chelly (Paris, F)
Breakthroughs in molecular and cellular mechanisms underlying X-linked mental retardation (45)
Hans van Bokhoven (Nijmegen)
Mutations in alphaPIX, a nucleotide exchange factor for Rho GTPases, in patients with X-linked mental retardation (15)
Rob Willemsen (Rotterdam)
Role of FMR1 protein in mental retardation (15)
Helger Yntema (Nijmegen)
Disrupted regulation of gene expression in (X-linked) mental retardation (15)
Ger Ramakers (Amsterdam)
Signal transduction through Rho proteins and the cell biology of mental retardation (30)
Ger Ramakers (Amsterdam) and Hans van Bokhoven (Nijmegen)
Closing remarks (15)

Session 27
Neuronal networks
(chair: Wytse Wadman, Ingrid van Welie and Corette Wierenga, Amsterdam)
Henry Markram (Rehovot, Israel)
Cellular, synaptic and network principles of neocortical microcircuit dynamics   (45)
Lovorka Pantic (Nijmegen)
On the role of dynamic synapses in coincidence detection and information processing (15)
Tonny Mulder (Amsterdam)
Analysis of the mesocorticolimbic network using tetrode recordings (30)
Martijn Meeter (Amsterdam)
TraceLink, a neural network model of memory and amnesia (15)

Session 28
Behavioral toxicity of MDMA in humans
(chair: Jan Ramaekers, Maastricht)
Andy Parrott (London, UK)
Psychobiological problems in recreational ecstasy/MDMA polydrug users (30)
Euphrosyne Gouzoulis-Mayfrank (Aachen, D)
Is ecstasy neurotoxic in humans? Evidence from neurocognitive studies (15)
Liesbeth Reneman (Amsterdam).
Cortical serotonin transporter density and verbal memory in individuals who stopped using MDMA (15)
Dick de Waard (Groningen)
The effects of MDMA on driving performance as measured in an advanced driving simulator (15)
Caroline Lamers (Maastricht)
The effects of MDMA on cognitive and psychomotor performance in recreational MDMA users (15)

Session 29
Brain inflammation in neuropsychiatric disorders
(chair: Jaap Korf, Groningen)
Piet Eikelenboom (Amsterdam)
Inflammation in Alzheimer and vascular brain diseases: state of the art (15)
Marianne Engelhart (Rotterdam)
Inflammatory mediators in Alzheimer's disease and vascular dementia: an epidemiological study (15)
Jeroen Hoozemans (Amsterdam)
Cyclo-oxygenase and prostaglandins in Alzheimer's disease brains: implications for drug therapy (15)
Jan Versijpt (Groningen/Gent, B)
SPECT imaging of brain inflammation in Alzheimer’s disease (15)
Gunter Kenis (Maastricht)
Effects of antidepressiva on cytokine production by CMS in rat, human and brain tissue (15)
Marieke Wichers (Maastricht)
Effects of interferon-alpha on the development of depression in relation to serotonin and the cytokine network (15) 
Michael Maes (Maastricht)
Inflammatory processes in depression and other neuropsychiatric disorders (15)